Zoppi G, Zamboni G
Eur J Pediatr. 1977 Jul 1;125(3):197-204. doi: 10.1007/BF00480597.
Five patients aged between 40 and 70 days were admitted to our Clinic with an initial diagnosis of "renal failure", but the high levels of urea nitrogen, metabolic acidosis and oliguria were found to be related to a high renal solute load and to the very high protein and electrolyte content of the diet. By calculating urinary output (V/m'), clearance of osmotically-active substances (COsm), clearance of free water (CH2O), maximum tubular reabsorption of water (TcH2O) and the change in metabolic H+ production, it has been possible to demonstrate that dietary protein and electrolytes were both responsible for the high blood urea nitrogen levels and metabolic acidosis.
5名年龄在40至70天之间的患儿因初步诊断为“肾衰竭”入住我们的诊所，但发现高尿素氮水平、代谢性酸中毒和少尿与高肾溶质负荷以及饮食中极高的蛋白质和电解质含量有关。通过计算尿量（V/m'）、渗透活性物质清除率（COsm）、自由水清除率（CH2O）、肾小管最大水重吸收率（TcH2O）以及代谢性H⁺产生的变化，已证实饮食中的蛋白质和电解质均是导致高血尿素氮水平和代谢性酸中毒的原因。
