异常核小体：染色质的功能特化

Deviant nucleosomes: the functional specialization of chromatin.

作者信息

Wolffe A P, Pruss D

机构信息

Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2710, USA.

出版信息

Trends Genet. 1996 Feb;12(2):58-62. doi: 10.1016/0168-9525(96)81401-6.

DOI:10.1016/0168-9525(96)81401-6

PMID:8851972

Abstract

Regulatory proteins exist with strong sequence and structural similarities to the histone proteins. Molecular genetic and cell biological analyses suggest that these proteins are localized at particular sites within the chromosome. Their assembly into nucleosomal structures confers specialized functions to individual chromosomal domains.

摘要

调节蛋白与组蛋白在序列和结构上存在很强的相似性。分子遗传学和细胞生物学分析表明，这些蛋白定位于染色体内的特定位点。它们组装成核小体结构赋予了各个染色体结构域特定的功能。