Hata M, Nakayama T, Hattori T, Okano S, Ito T, Abe T, Kamakura M, Iinuma H, Okinaga K, Yasuda K
Teikyo Univ. School of Med. Pediatrics.
Rinsho Ketsueki. 1996 Feb;37(2):129-33.
Ten year old boy with acute promyelocytic leukemia (APL) was treated with all-trans retinoic acid (ATRA). Immediately after the oral administration of ATRA (nine mg/m2 three times a day), DIC was controlled, and complete remission was achieved at day 39. The patient received ATRA therapy for 47 days, and then followed by conventional chemotherapy. Plasma ATRA level after 90 minutes of drug administration was 84.6 ng/ml. The superoxide generating activity of neutrophils in the bone marrow and peripheral blood was measured by chemiluminescence. The phagocytic function of neutrophils was markedly reduced in the ATRA-induced remission period, and was normal in the chemotherapy-induced remission. APL could be induced complete remission by three divided small doses of ATRA, and the ATRA-induced differentiated neutrophils might have lower phagocytic function.
一名10岁急性早幼粒细胞白血病（APL）男孩接受了全反式维甲酸（ATRA）治疗。口服ATRA（9mg/m²，每日3次）后，弥散性血管内凝血（DIC）立即得到控制，并在第39天实现完全缓解。该患者接受ATRA治疗47天，随后进行常规化疗。给药90分钟后的血浆ATRA水平为84.6ng/ml。通过化学发光法测量骨髓和外周血中性粒细胞的超氧化物生成活性。在ATRA诱导的缓解期，中性粒细胞的吞噬功能明显降低，而在化疗诱导的缓解期则正常。小剂量分三次给予ATRA可诱导APL完全缓解，且ATRA诱导分化的中性粒细胞吞噬功能可能较低。
