Tsukada T, Mahmud N, Taniguchi M, Takahashi T, Kihira H, Kita K, Kobayashi T, Deguchi K, Shirakawa S
Second Department of Internal Medicine, Mie University School of Medicine.
Rinsho Ketsueki. 1992 Dec;33(12):1880-3.
A 41-year-old man with untreated acute promyelocytic leukemia (APL) was treated with all-trans retinoic acid (ATRA) 80mg/body/day per os. Complete remission was reached in 16 day without bone marrow hypoplasia and aggravated disseminated intravascular coagulation. The chromosomal abnormality, t (15;17), which presented before therapy has not been found since the 29th day of therapy. During the course of induction therapy with ATRA, there was no complication worth of mentioning. Induction therapy with ATRA is thought to be more effective and safer than conventional chemotherapy to attain complete remission in APL. The complete remission has been maintained for 11 months with conventional postremission chemotherapy.
一名41岁未经治疗的急性早幼粒细胞白血病（APL）男性患者接受全反式维甲酸（ATRA）口服治疗，剂量为80mg/体/天。16天时达到完全缓解，未出现骨髓发育不全和严重弥散性血管内凝血加重的情况。治疗前出现的染色体异常t（15；17）自治疗第29天起未再发现。在使用ATRA进行诱导治疗过程中，没有值得一提的并发症。ATRA诱导治疗被认为比传统化疗在APL中实现完全缓解更有效、更安全。通过传统的缓解后化疗，完全缓解状态已维持了11个月。
