Misasi R S, Keyes J L
Crit Care Nurse. 1996 Jun;16(3):23-7, 31-8; quiz 39-40.
Arterial blood-gas composition is determined by ventilation, pulmonary blood flow, and by how ventilation is matched to blood flow in the lungs. In healthy adults there are regional differences in both ventilation and blood flow in the lungs and the distribution of blood flow tends to parallel that of ventilation. Ventilation and blood flow can become mismatched in a variety of disease processes that affect the lungs. Mismatching of ventilation and perfusion causes decreased PaO2, may change PaCO2, and increases AaDO2 difference. Many different types of interventions are frequently necessary to treat mismatching of ventilation and perfusion.
动脉血气成分由通气、肺血流量以及通气与肺内血流的匹配方式决定。在健康成年人中，肺内通气和血流存在区域差异，且血流分布往往与通气分布平行。在多种影响肺部的疾病过程中，通气和血流可能会出现不匹配。通气与灌注不匹配会导致动脉血氧分压（PaO2）降低，可能改变动脉血二氧化碳分压（PaCO2），并增大肺泡-动脉血氧分压差（AaDO2）。治疗通气与灌注不匹配通常需要多种不同类型的干预措施。
