生长激素对巴氯芬的反应：健康男性中10毫克和20毫克剂量的比较。
Growth hormone response to baclofen: a comparison of 10-mg and 20-mg doses in healthy men.
作者信息
Davis L L, Trivedi M, Kramer G L, Rush A J, Orsulak P J, Akers L, Petty F
机构信息
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.
出版信息
Psychiatry Res. 1996 Feb 28;60(1):41-7. doi: 10.1016/0165-1781(96)02874-0.
Growth hormone (GH) response and baclofen levels were measured in seven healthy adult men following a 10-mg and a 20-mg dose of oral baclofen (gamma-aminobutyric acidB agonist) to determine the preferred dose in baclofen challenge studies. Multivariate analysis of variance (ANOVA) with repeated measures revealed no differences between the doses. However, when a univariate ANOVA with repeated measures was performed for each dose, the 10-mg dose showed no significant GH response over time, whereas the 20-mg dose showed a significant GH response over time. The average delta GH (change in GH from baseline) was 7.84 ng/ml (SD = 10.17) for the 10-mg dose and 3.34 ng/ml (SD = 3.64) for the 20-mg dose. The variability in the delta GH response to the 10-mg dose was significantly greater than the response to the 20-mg dose of baclofen. This variance in GH response was not explained by the differences in serum baclofen levels. Thus, a 20-mg baclofen dose appears to be preferable to a 10 mg-dose in baclofen challenge studies.
在七名健康成年男性口服10毫克和20毫克剂量的巴氯芬（γ-氨基丁酸B激动剂）后，测量生长激素（GH）反应和巴氯芬水平，以确定巴氯芬激发试验中的最佳剂量。重复测量的多变量方差分析（ANOVA）显示各剂量之间无差异。然而，当对每个剂量进行重复测量的单变量方差分析时，10毫克剂量随时间推移未显示出显著的GH反应，而20毫克剂量随时间推移显示出显著的GH反应。10毫克剂量的平均GH变化量（相对于基线的GH变化）为7.84纳克/毫升（标准差 = 10.17），20毫克剂量为3.34纳克/毫升（标准差 = 3.64）。10毫克剂量的GH反应变异性显著大于20毫克剂量的巴氯芬反应。血清巴氯芬水平的差异无法解释GH反应的这种变异性。因此，在巴氯芬激发试验中，20毫克的巴氯芬剂量似乎优于10毫克剂量。
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