Yeragani V K, Srinivasan K, Balon R, Berchou R
Wright State University School of Medicine and Dayton VA Medical Center, OH 45428, USA.
Psychiatry Res. 1996 Feb 28;60(1):77-85. doi: 10.1016/0165-1781(95)02860-9.
Baroreceptor reflex sensitivity, coherence functions, and transfer functions between respiration and heart rate, and between respiration and blood pressure, were studied in nine normal volunteers before and after intravenous sodium lactate infusions. Cross-spectral analysis was used to examine heart rate, finger blood pressure, and respiration obtained with the subjects in a supine posture during spontaneous breathing. Sodium lactate produced a significant decrease of the modulus between respiration and heart rate (beats/min/l). There was no such change for the placebo infusions. The absence of a significant difference in the modulus between systolic blood pressure and heart rate for placebo or lactate indicated that there were no significant changes in the baroreceptor sensitivity index. These findings suggest that lactate infusions are associated with a decrease in cardiac vagal function.
在9名正常志愿者静脉输注乳酸钠前后，研究了压力感受器反射敏感性、呼吸与心率之间以及呼吸与血压之间的相干函数和传递函数。采用交叉谱分析方法，检测了受试者在自主呼吸时仰卧位的心率、手指血压和呼吸情况。乳酸钠使呼吸与心率之间的模量（次/分钟/升）显著降低。安慰剂输注则无此变化。安慰剂或乳酸钠输注后收缩压与心率之间的模量无显著差异，表明压力感受器敏感性指数无显著变化。这些研究结果提示，输注乳酸钠与心脏迷走神经功能降低有关。
