Yeragani V K, Srinivasan K, Pohl R, Berger R, Balon R, Berchou R
Wright University School of Medicine, Dayton, OH, USA.
Psychiatry Res. 1994 Oct;54(1):97-114. doi: 10.1016/0165-1781(94)90068-x.
We used spectral analysis of heart rate (HR), blood pressure (BP), and respiration to examine the effects of lactate on cholinergic and adrenergic influences on HR and BP variability, a technique found to be very useful in cardiovascular research. We specifically used high frequency (0.2-0.5 Hz) and midfrequency (0.07-0.15 Hz) powers to study cholinergic and adrenergic activity in nine normal control subjects before and after lactate and placebo infusions. Our results demonstrate a marked decrease in cholinergic activity and a significant increase in sympathovagal ratios of HR modulation after lactate infusions. This altered sympathovagal balance may contribute to the panicogenic effects of lactate in panic disorder patients.
我们采用心率（HR）、血压（BP）和呼吸的频谱分析来研究乳酸对胆碱能和肾上腺素能对心率和血压变异性影响的作用，这是一种在心血管研究中非常有用的技术。我们特别使用高频（0.2 - 0.5赫兹）和中频（0.07 - 0.15赫兹）功率，来研究在输注乳酸和安慰剂前后，九名正常对照受试者的胆碱能和肾上腺素能活性。我们的结果表明，输注乳酸后，胆碱能活性显著降低，心率调节的交感迷走神经比率显著增加。这种交感迷走神经平衡的改变可能导致惊恐障碍患者中乳酸的致惊恐效应。
