用鸟分枝杆菌敏感素来进行皮肤试验，以识别囊性纤维化患者是否感染鸟分枝杆菌复合群。

Skin testing with Mycobacterium avium sensitin to identify infection with M. avium complex in patients with cystic fibrosis.

作者信息

Pinto-Powell R, Olivier K N, Marsh B J, Donaldson S, Parker H W, Boyle W, Knowles M, Magnusson M, von Reyn C F

机构信息

Infectious Disease Section, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.

出版信息

Clin Infect Dis. 1996 Mar;22(3):560-2. doi: 10.1093/clinids/22.3.560.

DOI:10.1093/clinids/22.3.560

PMID:8852979

Abstract

We sought to determine if patients with cystic fibrosis and sputum cultures positive for Mycobacterium avium complex (MAC) have delayed-type hypersensitivity to an M. avium sensitin. Seventeen (33%) of 51 selected patients had MAC isolated from at least one sputum culture. Skin tests with purified protein derivative and M. avium sensitin demonstrated that five (10%) of 51 patients were anergic, and anergy was correlated with use of systemic steroids. Sixteen (35%) of 46 nonanergic patients had M. avium-dominant skin test reactions. Twelve (75%) of these 16 patients with cultures positive for MAC had M. avium-dominant skin tests; the specificity of skin testing was 87%. These data suggest that most patients with cystic fibrosis and sputum cultures positive for MAC have infection rather than colonization with MAC. Skin testing with M. avium sensitin is a sensitive and specific method for screening these infections.

摘要

我们试图确定囊性纤维化患者且鸟分枝杆菌复合群（MAC）痰培养呈阳性者是否对鸟分枝杆菌变应原具有迟发型超敏反应。在51例入选患者中，17例（33%）至少有一次痰培养分离出MAC。用纯化蛋白衍生物和鸟分枝杆菌变应原进行皮肤试验表明，51例患者中有5例（10%）无反应，且无反应与全身用类固醇的使用相关。46例有反应的患者中有16例（35%）对鸟分枝杆菌为主的皮肤试验有反应。这16例MAC培养阳性患者中有12例（75%）对鸟分枝杆菌为主的皮肤试验有反应；皮肤试验的特异性为87%。这些数据表明，大多数囊性纤维化且MAC痰培养呈阳性的患者是MAC感染而非定植。用鸟分枝杆菌变应原进行皮肤试验是筛查这些感染的一种敏感且特异的方法。