从几内亚比绍有呼吸道症状患者中分离出的鸟分枝杆菌复合群痰液菌株。

Mycobacterium avium complex sputum isolates from patients with respiratory symptoms in Guinea-Bissau.

作者信息

Koivula T, Hoffner S, Winqvist N, Nauclér A, Dias F, Lacerda L, Svenson S, Norberg R, Källenius G

机构信息

Swedish Institute for Infectious Disease Control, Karolinska Institute, Stockholm, Sweden.

出版信息

J Infect Dis. 1996 Jan;173(1):263-5. doi: 10.1093/infdis/173.1.263.

DOI:10.1093/infdis/173.1.263

PMID:8537673

Abstract

In total, 814 patients with clinically suspected tuberculosis were examined at the Raoul Follerau Hospital in Bissau, Guinea-Bissau. Sputum samples were collected, and cultures were grown on Löwenstein-Jensen medium. Isolates were further characterized by standard biochemical methods and nucleic acid probes for Mycobacterium tuberculosis and Mycobacterium avium complex (MAC). Serum samples were collected and analyzed for antibodies against human immunodeficiency virus (HIV) types 1 and 2. Of 17 patients who had MAC organisms in sputum, 2 were HIV-2-positive and none was HIV-1-positive. Of the total 814 patients, 189 had culture-verified tuberculosis; 36 (19%) of them were HIV-2-positive. Thus, of 206 patients with sputum culture positive for M. tuberculosis or MAC, 17 (8%) had MAC organisms in sputum. MAC infection may be the cause of some treatment failures in areas where MAC pulmonary infection is common.

摘要

在几内亚比绍比绍的拉乌尔·福勒劳医院，总共对814名临床疑似结核病患者进行了检查。采集了痰液样本，并在罗-琴培养基上进行培养。分离株通过标准生化方法以及针对结核分枝杆菌和鸟分枝杆菌复合群（MAC）的核酸探针进一步鉴定。采集血清样本并分析针对1型和2型人类免疫缺陷病毒（HIV）的抗体。在痰液中发现有MAC菌的17名患者中，2名HIV-2阳性，无HIV-1阳性。在总共814名患者中，189名经培养证实患有结核病；其中36名（19%）为HIV-2阳性。因此，在206名痰液培养结核分枝杆菌或MAC呈阳性的患者中，17名（8%）痰液中有MAC菌。在MAC肺部感染常见的地区，MAC感染可能是一些治疗失败的原因。