Audisio R A, Veronesi P, Maisonneuve P, Chiappa A, Andreoni B, Bombardieri E, Geraghty J G
Division of General Surgery, European Institute of Oncology, Milan, Italy.
Surg Oncol. 1996 Apr;5(2):49-63. doi: 10.1016/s0960-7404(96)80001-6.
Pancreatic adenocarcinoma is a relatively common malignancy and its incidence is increasing. Prognosis in these patients is poor, and surgery, the only effective treatment, saves only a minority of patients. The number in this small group of patients might be increased by early detection of pancreatic tumours. This review examines the current status of pancreatic tumour associated proteins in the detection of pancreatic cancer. As well as existing markers, the review also reports on newer markers that may offer advantages over existing ones in the detection of pancreatic adenocarcinoma. This is particularly important because recent studies have identified high-risk groups susceptible to pancreatic cancer. Future research in pancreatic cancer should be directed at earlier detection, and tumour markers may play an important role in this process.
胰腺腺癌是一种相对常见的恶性肿瘤，其发病率正在上升。这些患者的预后较差，而手术作为唯一有效的治疗方法，仅能挽救少数患者。早期发现胰腺肿瘤可能会增加这一小部分患者的数量。本综述探讨了胰腺肿瘤相关蛋白在胰腺癌检测中的现状。除了现有的标志物外，本综述还报告了一些新的标志物，这些标志物在检测胰腺腺癌方面可能比现有标志物更具优势。这一点尤为重要，因为最近的研究已经确定了易患胰腺癌的高危人群。未来胰腺癌的研究应致力于早期检测，而肿瘤标志物可能在这一过程中发挥重要作用。
