Adak G K, Wall P G, Smith H R, Cheasty T, Bolton F J, Griffin M A, Rowe B
Gastrointestinal Diseases Section, PHLS Communicable Disease Surveillance Centre.
Commun Dis Rep CDR Rev. 1996 Sep 13;6(10):R144-6.
Infection with Vero cytotoxin producing Escherichia coli O157 (VTEC O157) is a growing public health problem and the commonest cause of acute renal failure in children in the United Kingdom. Foodborne outbreaks of VTEC O157 infection have been reported in the United Kingdom, other European countries, and North America. Most cases of infection are sporadic, however, and the contribution of food vehicles, animal contact, and person to person spread in the acquisition of infection needs to be clarified. The PHLS is starting a case control study in England to identify and estimate the relative importance of risk factors for the acquisition of VTEC O157 infection. The study will run for 12 months. This article describes its objectives and asks microbiologists, public health physicians, clinicians, and others who may be asked for details about cases or to find suitable controls for their help in achieving a successful outcome.
感染产志贺毒素大肠杆菌O157（VTEC O157）是一个日益严重的公共卫生问题，也是英国儿童急性肾衰竭最常见的病因。在英国、其他欧洲国家和北美均有食源性VTEC O157感染暴发的报道。然而，大多数感染病例为散发病例，食物载体、动物接触以及人际传播在感染获得过程中的作用尚需阐明。英国公共卫生实验室服务处正在英格兰开展一项病例对照研究，以确定并评估获得VTEC O157感染的危险因素的相对重要性。该研究将持续12个月。本文介绍了其研究目的，并呼吁微生物学家、公共卫生医师、临床医生以及其他可能被要求提供病例详细信息或寻找合适对照的人员，协助研究取得成功。
