McDonnell R J, Rampling A, Crook S, Cockcroft P M, Wilshaw G A, Cheasty T, Stuart J
Public Health Laboratory, West Dorset Hospital, Dorchester.
Commun Dis Rep CDR Rev. 1997 Dec 12;7(13):R201-5.
An outbreak of food poisoning due to Escherichia coli O157 phage type 2 Vero cytotoxin 2 affected 26 people in southern counties of England in May and June 1995. The organism was isolated from faecal specimens from 23 patients, 16 of whom lived in Dorset and seven in Hampshire. Isolates were indistinguishable by phage typing, Vero cytotoxin gene typing, restriction fragment length polymorphism, and pulsed field gel electrophoresis. Three associated cases, linked epidemiologically to the outbreak, were confirmed serologically by detection of antibodies to E. coli O157 lipopolysaccharide. Twenty-two of the 26 patients were adults: four were admitted to hospital with haemorrhagic colitis. Four cases were children: two were admitted to hospital with haemolytic uraemic syndrome (HUS). There were no deaths. Although E. coli O157 was not isolated from any food samples, illness was associated with having eaten cold meats in sandwiches bought from two sandwich producers, in Weymouth and in Portsmouth. Both shops were supplied by the same wholesaler, who kept no records and obtained cooked meats from several sources in packs that did not carry adequate identification marks. It was, therefore, impossible to trace back to the original producer or to investigate further to determine the origin of contamination with E. coli O157. To protect the public health it is essential that all wholesale packs of ready-to-eat food carry date codes and the producer's identification mark. Detailed record keeping should be part of hazard analysis critical control point (HACCP) systems and should be maintained throughout the chain of distribution from the producer to retail outlets.
1995年5月和6月，英格兰南部各郡爆发了一起由产vero细胞毒素2的2型大肠杆菌O157噬菌体引起的食物中毒事件，共有26人感染。从23名患者的粪便标本中分离出了该病菌，其中16人居住在多塞特郡，7人居住在汉普郡。通过噬菌体分型、vero细胞毒素基因分型、限制性片段长度多态性分析和脉冲场凝胶电泳，这些分离菌株无法区分。通过检测抗大肠杆菌O157脂多糖抗体，血清学确诊了3例与此次疫情有流行病学关联的病例。26名患者中有22名是成年人，其中4人因出血性结肠炎住院；4名儿童患者中有2人因溶血尿毒综合征（HUS）住院，无死亡病例。尽管未从任何食品样本中分离出大肠杆菌O157，但发病与食用从韦茅斯和朴茨茅斯的两家三明治生产商购买的三明治中的冷肉有关。两家商店的货源均来自同一家批发商，该批发商没有保存记录，从多个来源采购熟食，包装上没有足够的识别标记。因此，无法追溯到原始生产商，也无法进一步调查确定大肠杆菌O157的污染源头。为保护公众健康，所有即食食品的批发包装必须带有生产日期代码和生产商识别标记。详细的记录保存应成为危害分析与关键控制点（HACCP）系统的一部分，并应在从生产商到零售网点的整个分销链中保持。
