Greenstein V C, Halevy D, Zaidi Q, Koenig K L, Ritch R H
Department of Ophthalmology, New York University School of Medicine 10016, USA.
Vision Res. 1996 Feb;36(4):621-9. doi: 10.1016/0042-6989(95)00158-1.
The purpose of this study was to compare the effects of glaucoma, at different stages of the disease process, on the two color-opponent system and on the luminance system. Discrimination thresholds were measured along the two equiluminant cardinal color axes (RG and YV) and along an achromatic luminance axis (LD) in 27 patients with open-angle glaucoma (OAG) and in 13 glaucoma suspects. Patients with OAG showed increased thresholds along all three axes. The threshold increases correlated significantly with the level of visual field loss. For glaucoma suspects, thresholds were also increased along all three axes. A subgroup of patients with OAG, those with pigmentary glaucoma, showed minimal increases in threshold along the RG axis. To further investigate this finding an additional 15 patients, seven with primary OAG and eight with pigmentary glaucoma were run in a two-alternative forced-choice experiment. For patients with pigmentary glaucoma, thresholds were increased less along the RG axis. The results of the study for OAG patients and glaucoma suspects are consistent with deficits in the two color-opponent systems, and in the luminance system.
本研究的目的是比较青光眼在疾病进程的不同阶段对双色拮抗系统和亮度系统的影响。在27例开角型青光眼（OAG）患者和13例青光眼疑似患者中，沿着两条等亮度主色轴（RG和YV）以及一条消色差亮度轴（LD）测量辨别阈值。OAG患者在所有三条轴上的阈值均升高。阈值升高与视野缺损程度显著相关。对于青光眼疑似患者，所有三条轴上的阈值也升高。OAG患者的一个亚组，即色素性青光眼患者，在RG轴上的阈值升高最小。为了进一步研究这一发现，另外15例患者，7例原发性OAG患者和8例色素性青光眼患者进行了二选一强迫选择实验。对于色素性青光眼患者，在RG轴上阈值升高较少。OAG患者和青光眼疑似患者的研究结果与双色拮抗系统和亮度系统的缺陷一致。
