Bahnemann R, Jacobs M, Karbe E, Kaufmann W, Morawietz G, Nolte T, Rittinghausen S
Exp Toxicol Pathol. 1995 Sep;47(4):247-66. doi: 10.1016/S0940-2993(11)80259-9.
RITA (Registry of Industrial Toxicology Animal-data) is a pathology data base for the collection of validated histopathological data on tumours and potentially pre-neoplastic lesions observed in laboratory rodents. To enable a better comparison of information, standardized techniques for the preparation of histological slides have been established for all organs. The current paper describes the guidelines for organ sampling and trimming procedures applied in the RITA project, i.e. the number of sections to be taken, the direction in which an organ should be cut, the localization (anatomical site) from which a sample should be taken, and the size of an organ (or part of an organ) to be placed in cassettes for processing. Schematical illustrations and additional explanations are provided to support the proposed standardized procedures in histology laboratories.
RITA（工业毒理学动物数据登记处）是一个病理学数据库，用于收集在实验室啮齿动物身上观察到的已验证的肿瘤组织病理学数据以及潜在的癌前病变数据。为了更好地比较信息，已为所有器官建立了标准化的组织学切片制备技术。本文描述了RITA项目中应用的器官取样和修整程序指南，即要取的切片数量、器官的切割方向、取样的定位（解剖部位）以及放入盒中进行处理的器官（或器官的一部分）的大小。提供了示意图和额外的解释，以支持组织学实验室中提议的标准化程序。
