Anand M, Khanna R N, Misra D, Sharma H K
Indian J Physiol Pharmacol. 1977 Apr-Jun;21(2):124-4.
Fenitrothion (Sumithion), and organophosphorous insectide, was applied dermally to rats. Cholinesterase activity was measured in blood and brain. The concentration of the pesticide in blood plasma and acetylcholine in brain were estimated at different intervals. The maximum concentration of Fenitrothion in the plasma was found at 4 hrs while significantly elevated levels of acetylcholine were present in the brain till 24 hrs. The results suggest that the compound was readily absorbed by dermal route to produce inhibition of cholinesterase and a consequent persistent increase in brain acetylcholine.
杀螟硫磷（速灭松），一种有机磷杀虫剂，经皮肤涂抹于大鼠身上。测量了血液和大脑中的胆碱酯酶活性。在不同时间间隔估算血浆中农药的浓度以及大脑中乙酰胆碱的浓度。血浆中杀螟硫磷的最大浓度在4小时时出现，而大脑中乙酰胆碱水平显著升高一直持续到24小时。结果表明该化合物经皮肤途径易于吸收，从而抑制胆碱酯酶，并随之使大脑中的乙酰胆碱持续增加。
