Balat O, Verschraegen C F, Edwards C L, Silva E, Kudelka A P, Kavanagh J J
Department of Gynecology Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, USA.
Eur J Gynaecol Oncol. 1996;17(4):271-3.
Choriocarcinoma most commonly follows a molar pregnancy, but it may develop after any gestational event. If choriocarcinoma follows a term pregnancy, it is associated with an unfavorable outcome and a 60% survival rate. A 33 year female who had delivered a normal girl 4 months before, presented with a nodule on the scalp behind the right ear. The pathologic diagnosis was compatible with metastatic choriocarcinoma. This tumor did not respond to chemotherapy, and she died a year later of multiple liver and pulmonary metastases. The development of a choriocarcinoma following a full term pregnancy is associated with a poor prognosis. We suggest that patients who do not achieve a clinical or serological remission after EMA-CO treatment be considered for high dose chemotherapy such as transplant.
绒毛膜癌最常继发于葡萄胎妊娠，但也可能在任何妊娠事件后发生。如果绒毛膜癌继发于足月妊娠，则预后不良，生存率为60%。一名33岁女性，4个月前顺产一正常女婴，现右耳后头皮出现一个结节。病理诊断为转移性绒毛膜癌。该肿瘤对化疗无反应，一年后因多发肝肺转移死亡。足月妊娠后发生绒毛膜癌预后较差。我们建议，对于接受EMA-CO治疗后未达到临床或血清学缓解的患者，考虑进行高剂量化疗，如移植。
