Moody D E, Pomp D, Newman S, MacNeil M D
Department of Animal Science, Oklahoma State University, Stillwater 74078, USA.
J Anim Sci. 1996 Aug;74(8):1784-93. doi: 10.2527/1996.7481784x.
Three populations of Hereford cattle differing in inbreeding levels and genetic potential for growth were genotyped for seven DNA polymorphisms. The populations were compared to determine differences in allele frequency and genetic variation. Significant differences in allele frequency among the populations were found at six of the seven polymorphisms genotyped, and average genetic variation differed as expected when inbreeding levels were considered. Effects of several polymorphisms on growth and maternal EPD were evaluated for one population (Miles City Line 1 Herefords) using regression analysis. Substitution of a B allele for an A allele of the kappa-casein polymorphism accounted for significant decreases in direct birth weight and maternal 180-d gain from birth to weaning EPD explaining 15% and 8%, respectively, of EPD variability. Several other significant effects accounting for small portions of EPD variability were also detected.
对三个近亲繁殖水平和生长遗传潜力不同的赫里福德牛群体进行了七种DNA多态性的基因分型。对这些群体进行比较，以确定等位基因频率和遗传变异的差异。在所基因分型的七种多态性中的六种中，发现群体间等位基因频率存在显著差异，并且在考虑近亲繁殖水平时，平均遗传变异如预期的那样有所不同。使用回归分析对一个群体（米尔斯城1系赫里福德牛）评估了几种多态性对生长和母本预期子代差异（EPD）的影响。κ-酪蛋白多态性的A等位基因被B等位基因取代，导致直接出生体重和母本从出生到断奶的180天增重EPD显著降低，分别解释了EPD变异性的15%和8%。还检测到其他几种对EPD变异性有小部分影响的显著效应。
