Alcamí A, Smith G L
Sir William Dunn School of Pathology, University of Oxford, UK.
Trends Microbiol. 1996 Aug;4(8):321-6. doi: 10.1016/0966-842x(96)10051-2.
Poxviruses encode soluble interferon-gamma receptors (IFN-gamma Rs) that inhibit IFN-gamma activity and play a major role in virus pathogenesis. In contrast to the highly species specific cellular homologues, the vaccinia IFN-gamma R has novel broad species specificity. This has implications for the unknown origin and natural host(s) of vaccinia virus, the vaccine used for smallpox eradication.
