小单孢菌产生的大环内酯类抗生素M - 4365。I. 分类学、生产、分离、表征及性质
Macrolide antibiotics M-4365 produced by Micromonospora. I. Taxonomy, production, isolation, characterization and properties.
作者信息
Furumai T, Maezawa I, Matsuzawa N, Yano S, Yamaguchi T
出版信息
J Antibiot (Tokyo). 1977 Jun;30(6):443-9. doi: 10.7164/antibiotics.30.443.
PMID:885804
Abstract
A series of basic 16-membered macrolide antibiotics, M-4365 A1, A2, A3, G1, G2 and G3, were isolated from the culture broth of strain MCRL 0940 which is assigned to be a new species of Micromonospora and for which the name Micromonospora capillata sp. nov. is proposed. Among these antibiotics, M-4365 A2 and G2 showed strong inhibitory activity against Gram-positive and Gram-negative bacteria.
摘要
从菌株MCRL 0940的培养液中分离出一系列基本的16元大环内酯抗生素，即M-4365 A1、A2、A3、G1、G2和G3。该菌株被认定为小单孢菌属的一个新物种，并提议将其命名为毛细小单孢菌（Micromonospora capillata sp. nov.）。在这些抗生素中，M-4365 A2和G2对革兰氏阳性菌和革兰氏阴性菌均表现出强烈的抑制活性。
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