四种新抗生素：四癌素E1、E2、F和F-1。发酵、分离与特性研究。

Tetrocarcins E1, E2, F and F-1, new antibiotics. Fermentation, isolation and characterization.

作者信息

Tamaoki T, Kasai M, Shirahata K, Tomita F

出版信息

J Antibiot (Tokyo). 1982 Aug;35(8):979-84. doi: 10.7164/antibiotics.35.979.

DOI:10.7164/antibiotics.35.979

PMID:7142015

Abstract

New components of tetrocarcins (E1, E2, F and F-1) were found in the culture broth of Micromonospora chalcea KY 11091 that was known to produce tetrocarcins A, B and C. Tetrocarcin F-1 consisted of tetronolide and nitro sugar (tetronitrose). Tetrocarcins E1 and E2 consisted of F-1 and deoxy sugar (L-digitoxose). Tetrocarcin F consisted of F-1 and two deoxy sugars (their structures were not yet determined). They all showed antibacterial activities against Gram-positive bacteria and the specific activity decreased with decrease in the numbers of deoxy sugars attached to the aglycone.

摘要

在已知能产生四霉素A、B和C的铜色小单孢菌KY 11091的培养液中发现了四霉素的新组分（E1、E2、F和F-1）。四霉素F-1由四内酯和硝基糖（四硝基糖）组成。四霉素E1和E2由F-1和脱氧糖（L-洋地黄毒糖）组成。四霉素F由F-1和两种脱氧糖（其结构尚未确定）组成。它们对革兰氏阳性菌均表现出抗菌活性，且随着连接在苷元上的脱氧糖数量减少，比活性降低。