血清胰蛋白酶原-2在预测急性坏死性胰腺炎预后中的作用
Serum trypsinogen-2 in the prediction of outcome in acute necrotizing pancreatitis.
作者信息
Sainio V, Puolakkainen P, Kemppainen E, Hedström J, Haapiainen R, Kivisaari L, Stenman U H, Schröder T, Kivilaakso E
机构信息
Dept. II of Surgery, Helsinki University Central Hospital, Finland.
出版信息
Scand J Gastroenterol. 1996 Aug;31(8):818-24. doi: 10.3109/00365529609010359.
BACKGROUND
The accuracy of serum trypsinogen-2 in predicting the severity of acute necrotizing pancreatitis (ANP) was prospectively evaluated in 52 consecutive patients.
METHODS
A new sensitive immunofluorometric assay was used for serum trypsinogen-2,
RESULTS
Mean values during the first 24 h were 42.1 micrograms/l in control patients, 1435 micrograms/l in uncomplicated cases, and 4090 micrograms/l in complicated or fatal cases. There was a significant difference in serum trypsinogen-2 values between patients with uncomplicated and complicated disease (p = 0.002) already on admission. When a cutoff level of 1000 micrograms/l was used, patients with uncomplicated ANP were differentiated from patients with complicated ANP with a sensitivity of 91% and with a specificity of 71%.
CONCLUSIONS
The immunofluorometric assay of serum trypsinogen-2 is a sensitive and specific method for prediction of the severity of the disease in necrotizing pancreatitis.
背景
前瞻性评估了52例连续急性坏死性胰腺炎（ANP）患者血清胰蛋白酶原-2预测疾病严重程度的准确性。
方法
采用一种新的敏感免疫荧光分析法检测血清胰蛋白酶原-2。
结果
对照组患者最初24小时的平均值为42.1微克/升，非复杂性病例为1435微克/升，复杂性或致死性病例为4090微克/升。入院时，非复杂性疾病和复杂性疾病患者的血清胰蛋白酶原-2值存在显著差异（p = 0.002）。当使用1000微克/升的临界值时，非复杂性ANP患者与复杂性ANP患者得以区分，灵敏度为91%，特异性为71%。
结论
血清胰蛋白酶原-2的免疫荧光分析法是预测坏死性胰腺炎疾病严重程度的一种敏感且特异的方法。
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