Renshaw A A, Henske E P, Loughlin K R, Shapiro C, Weinberg D S
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School Boston, Massachusetts 02115, USA.
Cancer. 1996 Oct 15;78(8):1756-61. doi: 10.1002/(sici)1097-0142(19961015)78:8<1756::aid-cncr16>3.0.co;2-x.
Chromophobe renal cell carcinoma (RCC) is a distinctive subtype of RCC with a more favorable prognosis than clear cell RCC. We describe the pathologic features of 23 solitary cases and 2 cases with coexistent papillary RCCs, 7 of which developed metastases.
Cases were retrieved from the pathology files of our institutions. Clinical follow-up was obtained from the medical records. DNA analysis was performed on Feulgen-stained slides using image analysis.
Twenty-five cases were identified. All cases had characteristic pathologic features, including diffuse cytoplasmic reactivity for Hale's colloidal iron. DNA ploidy analysis of ten cases revealed a diploid pattern in five, a hyperdiploid pattern in four, and a hypodiploid pattern in one. Follow-up was available for 20 cases, and metastases developed in 7 (from 4 to 120 months after surgery). In 5 of these cases, the tumors were solitary and more than 8 cm in greatest dimension and metastases developed in the liver. In both cases with papillary RCCs in the same kidney, metastases developed in the lung, although which tumor metastasized is unknown.
Despite the overall favorable prognosis for chromophobe RCC, large tumors and those with coexistent papillary RCCs may produce in metastases.
嫌色性肾细胞癌（RCC）是肾细胞癌的一种独特亚型，其预后比透明细胞肾细胞癌更有利。我们描述了23例孤立性病例以及2例合并乳头状肾细胞癌病例的病理特征，其中7例发生了转移。
病例取自我们机构的病理档案。临床随访信息来自病历记录。使用图像分析对福尔根染色切片进行DNA分析。
共鉴定出25例病例。所有病例均具有特征性病理特征，包括对黑尔胶体铁呈弥漫性细胞质反应。对10例病例进行DNA倍体分析，结果显示5例为二倍体模式，4例为超二倍体模式，1例为亚二倍体模式。20例病例有随访信息，7例发生转移（术后4至120个月）。其中5例病例中，肿瘤为孤立性，最大直径超过8 cm，转移至肝脏。在同一肾脏中合并乳头状肾细胞癌的2例病例中，均发生了肺转移，尽管不清楚是哪种肿瘤发生了转移。
尽管嫌色性肾细胞癌总体预后良好，但大肿瘤以及合并乳头状肾细胞癌的肿瘤可能会发生转移。
