Renshaw A A, Lee K R, Madge R, Granter S R
Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts, USA.
Acta Cytol. 1997 Jul-Aug;41(4):987-94. doi: 10.1159/000332777.
To evaluate the cytologic features of each subtype of renal cell carcinoma (RCC) for separating the various subtypes.
Thirty-eight renal fine needle aspiration (FNA) specimens with surgical resection follow-up were retrospectively reviewed and classified without knowledge of the resection specimen diagnosis. These included 18 clear cell RCCs, 8 papillary RCCs, 4 oncocytomas, 2 chromophobe RCCs, 2 sarcomatoid RCCs and 4 metastases to the kidney.
Seventy-four percent of the primary renal lesions were correctly classified. All 4 oncocytomas and the 2 chromophobe tumors were correctly classified, while both sarcomatoid RCCs and 3 of 8 papillary RCCs were misclassified as clear cell RCC. One clear cell RCC was misclassified as papillary type. Two clear cell and one papillary RCC were nondiagnostic; in each case the tumor had a prominent cystic component. All four metastases were correctly identified.
Subclassification of RCC by FNA is relatively accurate. In this study, the most common error was to misclassify papillary and sarcomatoid RCC as clear cell RCC.
评估肾细胞癌（RCC）各亚型的细胞学特征以区分不同亚型。
对38例接受手术切除随访的肾细针穿刺（FNA）标本进行回顾性分析，在不知切除标本诊断结果的情况下进行分类。其中包括18例透明细胞RCC、8例乳头状RCC、4例嗜酸细胞瘤、2例嫌色细胞RCC、2例肉瘤样RCC以及4例肾转移瘤。
74%的原发性肾病变被正确分类。所有4例嗜酸细胞瘤和2例嫌色细胞瘤均被正确分类，而2例肉瘤样RCC以及8例乳头状RCC中的3例被误分类为透明细胞RCC。1例透明细胞RCC被误分类为乳头状类型。2例透明细胞RCC和1例乳头状RCC无法诊断；在每种情况下，肿瘤均有显著的囊性成分。所有4例转移瘤均被正确识别。
通过FNA对RCC进行亚型分类相对准确。在本研究中，最常见的错误是将乳头状和肉瘤样RCC误分类为透明细胞RCC。
