Lowe N J, Maxwell A, Harper H
Skin Research Foundation of California, Santa Monica, USA.
J Am Acad Dermatol. 1996 Oct;35(4):569-72. doi: 10.1016/s0190-9622(96)90682-9.
Botulinum A exotoxin (BTX) has been used successfully to treat a variety of hyperkinetic movement disorders. BTX is also capable of reducing hyperkinetic facial lines including prominent glabellar frown lines.
The purposes of this study were to (1) confirm the efficacy of BTX in a double-blind, placebo-controlled investigation; (2) evaluate the use of an electromyogram attached to the injection needle to confirm intramuscular corrugator placement of the BTX; and (3) determine the optimum direction injection technique.
Length and depth of glabellar frown lines were measured before treatment and 4 and 12 weeks after injection of 10 units of BTX or saline solution.
Patients treated with BTX had a highly significant reduction in depth and length of glabellar frown lines compared with control subjects.
BTX appears to be effective and safe for reduction of glabellar frown lines.
A型肉毒杆菌毒素（BTX）已成功用于治疗多种运动亢进性疾病。BTX还能够减少包括眉间皱纹在内的面部运动亢进性皱纹。
本研究的目的是：（1）在双盲、安慰剂对照研究中确认BTX的疗效；（2）评估使用连接到注射针的肌电图来确认BTX在肌肉内皱眉肌的定位；（3）确定最佳注射方向技术。
在治疗前以及注射10单位BTX或生理盐水溶液后4周和12周测量眉间皱纹的长度和深度。
与对照组相比，接受BTX治疗的患者眉间皱纹的深度和长度显著减少。
BTX似乎对减少眉间皱纹有效且安全。
