Song K H
Professional Product Information, Roche Laboratories, Inc., Nutley, NJ 07110, USA.
Ann Pharmacother. 1998 Dec;32(12):1365-7. doi: 10.1345/aph.18128.
Patients who have exaggerated frown lines frequently ask for treatment because others mistake them to be constantly angry or annoyed. Current treatment options (surgery or implants) do not address the underlying cause of these lines, namely the excessive nerve stimulation. The mechanism of action of BTX makes it an ideal agent to target the major cause of these lines. BTX inhibits calcium metabolism in the presynaptic neuron, thereby inhibiting neuromuscular transmission and producing muscle paralysis. The current medical literature indicates that BTX can be used safely and effectively for the cosmetic treatment of frown lines. The procedure can be performed in an ambulatory setting and the use of an EMG instrument may provide better direction for the placement of the drug. However, the benefits are transient and repeated injections are necessary. The adverse effects associated with BTX injections were mild and transient. Currently, there are no safety data on the long-term effects of continuous BTX injections for the treatment of frown lines. However, studies on the long-term use of BTX at doses to treat blepharospasm and Meige's disease have shown no serious adverse effects or production of antibodies to BTX. Muscle biopsies taken from patients who have received numerous doses of BTX for more than 7 years have not shown any signs of atrophy or permanent muscle degeneration. The medical literature supports BTX therapy as an option for the treatment of cosmetic facial frown lines. However, there is not enough information on what patient characteristics are ideal in a candidate to achieve optimal response with BTX. Also, no data are available on the safety and efficacy of continuous injections in the long-term use of BTX for facial frown lines. Therefore, the use of BTX to treat frown lines should be examined carefully against other therapeutic options.
经常出现夸张皱眉纹的患者常寻求治疗，因为其他人会误以为他们总是生气或恼怒。目前的治疗选择（手术或植入物）并未解决这些皱纹的根本原因，即神经刺激过度。肉毒杆菌毒素（BTX）的作用机制使其成为针对这些皱纹主要成因的理想药物。BTX抑制突触前神经元中的钙代谢，从而抑制神经肌肉传递并导致肌肉麻痹。当前医学文献表明，BTX可安全有效地用于皱眉纹的美容治疗。该 procedure 可在门诊环境中进行，使用肌电图仪可能为药物注射位置提供更好的指导。然而，效果是短暂的，需要重复注射。与BTX注射相关的不良反应轻微且短暂。目前，尚无关于连续注射BTX治疗皱眉纹长期影响的安全性数据。然而，对用于治疗眼睑痉挛和梅杰氏病的剂量的BTX长期使用研究表明，没有严重不良反应或产生针对BTX的抗体。对接受多次BTX注射超过7年的患者进行的肌肉活检未显示任何萎缩或永久性肌肉退化迹象。医学文献支持将BTX治疗作为面部美容皱眉纹的一种治疗选择。然而，关于何种患者特征对于使用BTX获得最佳反应最为理想，尚无足够信息。此外，关于长期使用BTX连续注射治疗面部皱眉纹的安全性和有效性也没有数据。因此，应将使用BTX治疗皱眉纹与其他治疗选择进行仔细比较。
