Nyulassy S, Hnilica P, Buc M, Guman M, Hirschová V, Stefanovic J
J Clin Endocrinol Metab. 1977 Aug;45(2):270-4. doi: 10.1210/jcem-45-2-270.
The HLA antigens in 40 patients with subacute thyroiditis were investigated. An association between subacute thyroiditis and HLA-Bw35 antigen as previously reported, was confirmed. Further immunological observations included a decrease in Serum Clq, C4 and C3 activator levels; conversely, there was an increase in serum C3, IgM, alpha1-acid glycoprotein and alpha1-antitrypsin levels. Serum IgA levels were decreased in those patients who were Bw35 negative, but were normal in the patients who were Bw-35 positive, with serum alpha2-macroglobulin levels the opposite was found. These studies support the view that a genetic factor(s), viz., the major histocompatibility system, plays a role in the pathogenesis of subacute thyroiditis. A "nosological clustering" around the Bw35 antigen as a marker for viral susceptibility is suggested.
对40例亚急性甲状腺炎患者的HLA抗原进行了研究。如先前报道，证实了亚急性甲状腺炎与HLA - Bw35抗原之间存在关联。进一步的免疫学观察包括血清Clq、C4和C3激活剂水平降低；相反，血清C3、IgM、α1 - 酸性糖蛋白和α1 - 抗胰蛋白酶水平升高。Bw35阴性患者的血清IgA水平降低，但Bw - 35阳性患者的血清IgA水平正常，而血清α2 - 巨球蛋白水平则相反。这些研究支持了一种观点，即一个或多个遗传因素，即主要组织相容性系统，在亚急性甲状腺炎的发病机制中起作用。有人提出以Bw35抗原作为病毒易感性的标志物存在“疾病分类聚集”现象。
