Levi A J, Fisher A M, Hughes L, Hendry W F
Lancet. 1979 Aug 11;2(8137):276-8. doi: 10.1016/s0140-6736(79)90292-7.
Four young immigrants whose ulcerative colitis was controlled by sulphasalazine had oligospermia and infertility. No other cause for infertility was found in any of them nor in their wives. Findings on semen analyses rapidly improved in all patients on withdrawal of sulphasalazine, which resulted in four pregnancies in three of the wives. Reintroduction of sulphasalazine was followed by rapid deterioration in the semen of two patients. The frequency and importance of the effect of sulphasalazine on fertility requires further evaluation.
四名溃疡性结肠炎由柳氮磺胺吡啶控制的年轻移民患有少精子症和不育症。在他们任何一人及其妻子中均未发现其他不育原因。所有患者停用柳氮磺胺吡啶后精液分析结果迅速改善，三名妻子中有四名成功怀孕。两名患者重新使用柳氮磺胺吡啶后精液迅速恶化。柳氮磺胺吡啶对生育能力影响的频率和重要性需要进一步评估。
