Toth A
Fertil Steril. 1979 May;31(5):538-40. doi: 10.1016/s0015-0282(16)44000-8.
The semen qualities of six patients with salicylazosulfapyridine-treated chronic ulcerative colitis are discussed. Over-all poor parameters were observed during the treatment period. Reduced motility and a shift in morphology were the most significant abnormalities in the specimens. A characteristic megalo cell type occurred in the morphology with a frequency of 3% to 8%. In three patients when no medical contraindication existed, discontinuation of the drug resulted in a dramatic improvement in the semen quality, and all three reported pregnancies within the ensuing 3 months. A possible reversible toxic effect of salicylazosulfapyridine on semen quality is discussed.
本文讨论了6例接受柳氮磺胺吡啶治疗的慢性溃疡性结肠炎患者的精液质量。在治疗期间观察到总体参数较差。标本中最显著的异常是活力降低和形态改变。形态学上出现一种特征性的巨细胞类型，频率为3%至8%。在3例无医学禁忌证的患者中，停药后精液质量显著改善，且这3例患者均在随后3个月内报告怀孕。本文还讨论了柳氮磺胺吡啶对精液质量可能存在的可逆毒性作用。
