Fara G M, Del Corvo G, Bernuzzi S, Bigatello A, Di Pietro C, Scaglioni S, Chiumello G
Lancet. 1979 Aug 11;2(8137):295-7. doi: 10.1016/s0140-6736(79)90304-0.
An outbreak of breast enlargement in girls and boys attending a school in Milan, first noted in November, 1977, was followed up until the end of 1978. 213 boys aged 3-14 years and 110 girls aged 3-7 years were studied; control children attending five other schools were also examined. In total 1647 boys and 476 girls were examined. Breast enlargement was significantly more common in boys (29.0%) and girls (21.6%) aged 3-5 years, boys (58.0%) aged 6-10, and girls (67.1%) aged 6-7 from the school in Milan, than in age and sex matched children at control schools. Breast enlargement was not pronounced and disappeared within 8 months. Hormonal determinations were within normal limits except for 17 beta-oestradiol which was slightly raised. Although oestrogen contamination was not detected when samples of school meals were tested, an uncontrolled supply of poultry and beef was suspected as being the cause of this outbreak.
1977年11月首次发现米兰一所学校的男女生出现乳房增大情况，并持续跟踪至1978年底。对213名3至14岁的男孩和110名3至7岁的女孩进行了研究；还检查了在其他五所学校就读的对照儿童。总共检查了1647名男孩和476名女孩。米兰那所学校中3至5岁的男孩（29.0%）和女孩（21.6%）、6至10岁的男孩（58.0%）以及6至7岁的女孩（67.1%）出现乳房增大的情况明显比对照学校中年龄和性别匹配的儿童更为常见。乳房增大并不明显，且在8个月内消失。除17β-雌二醇略有升高外，激素测定均在正常范围内。虽然对学校餐食样本进行检测时未发现雌激素污染，但怀疑不受控制的家禽和牛肉供应是此次疫情的原因。
