Matsunari I, Tanishima Y, Taki J, Ono K, Nishide H, Fujino S, Matoba M, Ichiyanagi K, Tonami N
Department of Radiology, Fukui Prefectural Hospital, Japan.
J Nucl Med. 1996 Oct;37(10):1622-6.
This study was performed to test the feasibility of early SPECT imaging with 99mTc-tetrofosmin with the presence of high hepatic activity.
Thirteen normal volunteers were injected 600-740 MBq of 99mTc-tetrofosmin at rest and were imaged at 10 min and 1 hr after injection. The SPECT images were reconstructed for 180 degrees 360 degrees data. The early and delayed SPECT and anterior planar projection images were analyzed.
After excluding one subject because of high hepatic activity overlapping to the myocardium, 4 of 12 subjects (33%) had abnormal scans with reduced uptake in the inferior wall on the early 180 degrees SPECT image. In contrast, only one (8%) showed equivocally reduced uptake on the 360 degrees SPECT image. In the delayed images, all subjects had a normal 180 degrees and 360 degrees SPECT scan. Quantitative data showed reduced regional activities in the inferior wall on the early SPECT scan, especially in the 180 degrees data. There were no changes in the mean anterior-to-inferior ratio in the anterior planar projection images over time, suggesting that the reduced activity in the early SPECT images reflected an artifactual effect.
Our data indicate that it would be best to perform late imaging in patients with suspected coronary artery disease using 99mTc-tetrofosmin.
本研究旨在测试在肝脏摄取高活性的情况下，使用99mTc-替曲膦进行早期单光子发射计算机断层扫描（SPECT）成像的可行性。
13名正常志愿者在静息状态下注射600 - 740MBq的99mTc-替曲膦，并在注射后10分钟和1小时进行成像。SPECT图像采用180度和360度数据重建。对早期和延迟的SPECT及前位平面投影图像进行分析。
由于肝脏高活性与心肌重叠而排除一名受试者后，12名受试者中有4名（33%）在早期180度SPECT图像上显示下壁摄取减少的异常扫描。相比之下，在360度SPECT图像上只有一名（8%）显示摄取减少不明确。在延迟图像中，所有受试者的180度和360度SPECT扫描均正常。定量数据显示早期SPECT扫描时下壁区域活性降低，尤其是在180度数据中。在前位平面投影图像中，前壁与下壁的平均比值随时间无变化，表明早期SPECT图像中活性降低反映了一种伪影效应。
我们的数据表明，对于疑似冠状动脉疾病的患者，使用99mTc-替曲膦进行晚期成像可能是最佳选择。
