Barra R, Hall J C
J Exp Zool. 1977 Jul;201(1):93-9. doi: 10.1002/jez.1402010111.
The effects of alloxan-induced diabetes on liver regeneration were investigated. Normal and diabetic rats were sacrificed at eight time periods between 16 hours and 4 weeks following two-thirds partial hepatectomy or sham operation. The results indicate that alloxan-induced diabetes delays but does not prevent liver regeneration following partial hepatectomy. This delay is indicated by a depressed synthesis of RNA, DNA and protein during the first post-operative day and a lack of mitotic figures in the 24-hour sample. In addition, the synthesis of these three cellular constituents did not return to control levels as rapidly in the diabetics. Compared with the sham operated animals, the concentrations of total serum protein remained depressed longer in the diabetic hepatectomized animals. The data indicate that the metabolic alterations associated with alloxan diabetes delay the onset of the regenerative process and prolong the recovery period.
研究了四氧嘧啶诱导的糖尿病对肝脏再生的影响。正常大鼠和糖尿病大鼠在三分之二部分肝切除或假手术后的16小时至4周的八个时间段被处死。结果表明，四氧嘧啶诱导的糖尿病会延迟但不会阻止部分肝切除后的肝脏再生。这种延迟表现为术后第一天RNA、DNA和蛋白质合成受到抑制，以及在24小时样本中缺乏有丝分裂图像。此外，糖尿病大鼠中这三种细胞成分的合成没有那么快恢复到对照水平。与假手术动物相比，糖尿病肝切除动物的总血清蛋白浓度在更长时间内保持降低。数据表明，与四氧嘧啶糖尿病相关的代谢改变会延迟再生过程的开始并延长恢复期。
