Fosmire G J, Greeley S, Sandstead H H
J Nutr. 1977 Aug;107(8):1543-50. doi: 10.1093/jn/107.8.1543.
Some effects of various degrees of zinc deprivation during pregnancy have been examined in dams and offspring. After mating, the dams were fed a biotin enriched, 20% sprayed egg white diet which contained less than 1 ppm zinc. Zinc was provided in the drinking water at one of the following concentrations: 1, 2, 3, 5, 11, or 25 mg/liter. Pups were taken by cesarean section on day 22 of gestation. The dams given insufficient zinc became anorexic, particularly during the latter third of gestation. Anorexia occurred earlier and was most severe at the lowest levels of zinc intake. The decreased food consumption resulted in energy deprivation and at the lowest levels of zinc intake, in protein insufficiency. The total weight gain and rate of weight deposition in the dams were both functions of the level of zinc provided. Fetal growth and extent of zinc deposition into the fetuses were both related to the amount of zinc provided. The responses of dams and fetuses to the extent of zinc deprivation were not equivalent, however. It appeared that there was a sparing of fetal growth at the expense of the dam at very low levels of zinc intake. Conversely, at higher, but still suboptimal levels of zinc, the fetuses still experienced growth retardation although the dams attained a normal weight deposition during gestation.
研究了孕期不同程度缺锌对母鼠及其后代的一些影响。交配后，给母鼠喂食富含生物素、20%喷干蛋清的日粮，该日粮含锌量低于1 ppm。通过在饮水中添加锌，使其浓度分别为下列之一：1、2、3、5、11或25毫克/升。在妊娠第22天通过剖腹产取出幼崽。锌摄入不足的母鼠出现厌食，尤其在妊娠后期。厌食出现得更早，在锌摄入量最低时最为严重。食物摄入量减少导致能量缺乏，在锌摄入量最低时还导致蛋白质不足。母鼠的总体重增加和体重沉积率均与所提供的锌水平有关。胎儿生长和锌在胎儿体内的沉积程度均与所提供的锌量有关。然而，母鼠和胎儿对缺锌程度的反应并不相同。在锌摄入量极低时，似乎是以母鼠为代价来维持胎儿生长。相反，在锌水平较高但仍未达最佳水平时，尽管母鼠在妊娠期体重沉积正常，但胎儿仍出现生长迟缓。
