Thamavit W, Tiwawech D, Moore M A, Ito N, Shirai T
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Toxicol Pathol. 1996 Jul-Aug;24(4):493-7. doi: 10.1177/019262339602400412.
The effects of repeated infection with Opisthorchis viverrini on liver lesion development in male and female Syrian hamsters were investigated over a 1-yr period. Ten monthly intragastric applications of 50, 25, 13, or 0 parasite metacercariae resulted in pronounced proliferative and inflammatory lesions involving the first- and second-order ducts in response to the presence of adult worms. Despite the development of small numbers of putative preneoplastic areas of cholangiofibrosis and morphologically altered hepatocellular foci, no neoplastic lesions were evident at sacrifice after 1 yr. The results thus suggest that parasite infestation is itself not strongly carcinogenic if at all but, rather, that it exerts a marked promoting influence on cholangiocellular and hepatocellular tumor development in the hamster via chronic irritation and increased cell turnover.
在为期1年的时间里，研究了多次感染麝猫后睾吸虫对雄性和雌性叙利亚仓鼠肝脏病变发展的影响。每月通过胃内给药，分别给予50、25、13或0个寄生虫后尾蚴，连续给药10个月，结果发现，由于成虫的存在，一级和二级胆管出现了明显的增殖性和炎性病变。尽管出现了少量疑似胆管纤维化的癌前区域和形态改变的肝细胞灶，但在1年后处死时未发现明显的肿瘤病变。因此，结果表明，寄生虫感染本身即使有致癌作用也不强，而是通过慢性刺激和增加细胞更新，对仓鼠胆管细胞和肝细胞肿瘤的发展产生显著的促进作用。
