Roccatagliata A J, Maier M S, Seldes A M, Pujol C A, Damonte E B
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
J Nat Prod. 1996 Sep;59(9):887-9. doi: 10.1021/np960171a.
One new and three known sulfated steroidal polyols have been isolated from the ophiuroid Ophioplocus januarii, collected at San Antonio Oeste, Río Negro, Argentina. The four compounds possess 4 alpha,11 beta-dihydroxy-3 alpha,21-disulfoxy substituents and the A/B cis ring junction but differ in the side chain. The new compound has been characterized as (22E)-5 beta-24-norcholest-22-ene-3 alpha,4 alpha,11 beta,21-tetrol 3,21-disulfate (4). The structures of the four compounds were determined from spectral data and comparison with those of related steroidal polyols. The four compounds were tested for their inhibitory effect on the replication of one DNA and three RNA viruses. Compounds 2 and 4 were active against respiratory syncytial and polio viruses, and compound 3 inhibited Junin virus, responsible for Argentine hemorrhagic fever.
从采集于阿根廷内格罗河省圣安东尼奥-奥斯特的蛇尾类动物一月蛇尾（Ophioplocus januarii）中分离出了一种新的和三种已知的硫酸化甾体多元醇。这四种化合物都具有4α,11β-二羟基-3α,21-二磺氧基取代基以及A/B顺式环连接，但侧链有所不同。新化合物已被鉴定为(22E)-5β-24-降胆甾-22-烯-3α,4α,11β,21-四醇3,21-二硫酸盐（4）。通过光谱数据并与相关甾体多元醇的光谱数据进行比较确定了这四种化合物的结构。测试了这四种化合物对一种DNA病毒和三种RNA病毒复制的抑制作用。化合物2和4对呼吸道合胞病毒和脊髓灰质炎病毒有活性，化合物3抑制导致阿根廷出血热的胡宁病毒。
