Myers C E, Gluck M A
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA.
Behav Neurosci. 1996 Aug;110(4):685-706. doi: 10.1037//0735-7044.110.4.685.
A previous model of hippocampal region function in classical conditioning is generalized to H. Eichenbaum, A. Fagan, P. Mathews, and N.J. Cohen's (1989) and H. Eichenbaum, A. Fagan, and N.J. Cohen's (1989) simultaneous odor discrimination studies in rats. The model assumes that the hippocampal region forms new stimulus representations that compress redundant information while differentiating predictie information; the piriform (olfactory) cortex meanwhile clusters similar and co-occurring odors. Hippocampal damage interrupts the ability to differentiate odor representations, while leaving piriform-mediated odor clustering unchecked. The result is a net tendency to overcompress in the lesioned model. Behavior in the model is very similar to that of the rats, including lesion deficits, facilitation of successively learned tasks, and transfer performance. The computational mechanisms underlying model performance are consistent with the qualitative interpretations suggested by Eichen baum et al. to explain their empirical data.
先前关于经典条件作用中海马区功能的模型被推广应用于H. 艾肯鲍姆、A. 费根、P. 马修斯和N.J. 科恩（1989年）以及H. 艾肯鲍姆、A. 费根和N.J. 科恩（1989年）对大鼠进行的同时嗅觉辨别研究。该模型假设，海马区形成新的刺激表征，在区分预测信息的同时压缩冗余信息；与此同时，梨状（嗅觉）皮质对相似且同时出现的气味进行聚类。海马损伤会干扰区分气味表征的能力，而梨状皮质介导的气味聚类则不受影响。结果是，在受损模型中存在过度压缩的净趋势。模型中的行为与大鼠的行为非常相似，包括损伤缺陷、对相继学习任务的促进以及迁移表现。模型表现背后的计算机制与艾肯鲍姆等人提出的用于解释其实验数据的定性解释一致。
