Driscoll Ira, Sutherland Robert J, Prusky Glen T, Rudy Jerry W
Canadian Centre for Behavioural Neuroscience, Psychology & Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Behav Neurosci. 2004 Dec;118(6):1427-32. doi: 10.1037/0735-7044.118.6.1427.
Rats were trained on a set of visual discrimination problems (A+B-, C+D-, E+F-). The choice stimuli were then recombined to create novel combination tests (A+D-, C+F-, E+B-). Rats with damage to the hippocampus showed perfect transfer on these tests, always choosing A, C, and E, but were not able to learn the spatial location of the platform, indicating that damage to the hippocampus was functional. These results question the generality of H. Eichenbaum, P. Mathews, and N. J. Cohen's (1989) findings and the theoretical claim that choice behavior with novel combinations is based on inferential-like hippocampus-dependent processes (H. Eichenbaum, 1992). They are consistent with the view that simple associative processes guide choice behavior in animals with hippocampal damage that are confronted with novel combinations.
大鼠接受了一系列视觉辨别问题（A+B-，C+D-，E+F-）的训练。然后将选择刺激重新组合以创建新的组合测试（A+D-，C+F-，E+B-）。海马体受损的大鼠在这些测试中表现出完美的迁移能力，总是选择A、C和E，但无法学习平台的空间位置，这表明海马体损伤是功能性的。这些结果对H.艾肯鲍姆、P.马修斯和N.J.科恩（1989年）的研究结果以及关于新组合的选择行为基于类似推理的海马体依赖过程的理论主张（H.艾肯鲍姆，1992年）的普遍性提出了质疑。它们与这样一种观点一致，即简单的联想过程指导着海马体受损的动物在面对新组合时的选择行为。
