Mortlock S A, Langley R W, Bradshaw C M, Szabadi E
Department of Psychiatry, University of Nottingham, UK.
Br J Clin Pharmacol. 1996 Aug;42(2):236-8. doi: 10.1046/j.1365-2125.1996.39715.x.
The effect of locally applied prazosin on pupillometric measures was studied in healthy volunteers, in an attempt to identify the role of alpha 1-adrenoceptors in the recovery time of the light reflex. Prazosin antagonized the mydriatic effect of phenylephrine, but did not alter that of tropicamide. Miotic responses to a range of light stimuli were measured under ambient temperature conditions of 22 degrees C and 40 degrees C. The 40 degrees C condition was associated with shorter recovery times of the light reflex; prazosin increased the recovery time under both temperature conditions. Response amplitude was not affected by the temperature condition or prazosin. The results are consistent with the hypothesis that sympathetic neuromuscular transmission is involved in the redilatation of the pupil following a miotic response to light stimulation.
为了确定α1 -肾上腺素能受体在光反射恢复时间中的作用，研究人员在健康志愿者中研究了局部应用哌唑嗪对瞳孔测量指标的影响。哌唑嗪拮抗了去氧肾上腺素的散瞳作用，但未改变托吡卡胺的散瞳作用。在22摄氏度和40摄氏度的环境温度条件下，测量了对一系列光刺激的缩瞳反应。40摄氏度的条件与光反射的恢复时间较短有关；在两种温度条件下，哌唑嗪均增加了恢复时间。反应幅度不受温度条件或哌唑嗪的影响。这些结果与以下假设一致，即交感神经肌肉传递参与了对光刺激产生缩瞳反应后瞳孔的再扩张。
