Mrtek M B, Gearien J E, Blake M I
J Pharm Sci. 1977 Jul;66(7):1019-21. doi: 10.1002/jps.2600660731.
A complex of phenobarbital and ephedrine was prepared and characterized. The complex was differentiated from physical mixtures of the two drugs by TLC and IR spectroscopy. NMR spectroscopy was used to verify the proportion of each drug in the complex and to confirm the existence of intermolecular binding. Mass spectrometry was employed to establish that all fragments characteristic of the individual drug entities could be isolated from the complex. Elemental analysis confirmed the chemical composition of the complex. A possible chemical structure for the complex was hypothesized on the basis of the chemical and spectroscopic data.
制备并表征了苯巴比妥和麻黄碱的复合物。通过薄层色谱法（TLC）和红外光谱法将该复合物与两种药物的物理混合物区分开来。核磁共振光谱法用于验证复合物中每种药物的比例，并确认分子间结合的存在。采用质谱法确定可以从复合物中分离出各个药物实体的所有特征碎片。元素分析证实了复合物的化学组成。根据化学和光谱数据推测了该复合物可能的化学结构。
