Kaba S E, Langford L A, Yung W K, Kyritsis A P
Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, USA.
J Neurooncol. 1996 Oct;30(1):55-60. doi: 10.1007/BF00177443.
Ganglioglioma is an uncommon brain tumor with glial and neuronal cellular components and a somewhat benign course. We are presenting an unusual case of ganglioglioma with malignant transformation in both cellular components associated with an aggressive clinical course. An almost complete resolution of the recurrent progressing tumor was achieved after treatment with cis-retinoic acid (cRA) as a single agent. A possible differential effect of cRA on the neuronal component of the tumor is suggested.
神经节胶质瘤是一种罕见的脑肿瘤，具有神经胶质和神经元细胞成分，病程相对良性。我们报告了一例罕见的神经节胶质瘤病例，其两种细胞成分均发生恶性转化，临床病程侵袭性强。单用顺式维甲酸（cRA）治疗后，复发性进展性肿瘤几乎完全消退。提示cRA对肿瘤神经元成分可能有不同的作用。
