Gerber D A
J Rheumatol. 1977 Spring;4(1):40-5.
The longterm administration of prednisone and gold to patients with rheumatoid arthritis (RA), in doses that decreased the sedimentation rate (p less than 0.05), did not alter the serum histidine concentration (p greater than 0.5). In patients with RA receiving various combinations of aspirin, prednisone, and gold, the regression lines relating the serum histidine concentrations to the sedimentation rates had similar slopes but different elevations compared to patients receiving no anti-inflammatory drugs. In the patients receiving anti-inflammatory drugs, the regression lines were displaced so that in patients with similar serum histidine concentrations, the stronger the antirheumatic therapy, the less abnormal the sedimentation rate. These observations are consistent with the hypothesis that hypohistidinemia contributes to the pathogenesis of RA.
对类风湿性关节炎（RA）患者长期给予泼尼松和金制剂，剂量降低了血沉（p<0.05），但血清组氨酸浓度未改变（p>0.5）。在接受阿司匹林、泼尼松和金制剂不同组合的RA患者中，与未接受抗炎药的患者相比，血清组氨酸浓度与血沉相关的回归线斜率相似但截距不同。在接受抗炎药的患者中，回归线发生移位，因此在血清组氨酸浓度相似的患者中，抗风湿治疗越强，血沉异常程度越低。这些观察结果与低组氨酸血症参与RA发病机制的假说一致。
