类风湿关节炎中对羟氯喹和金硫葡糖反应的生化指标
Biochemical indices of response to hydroxychloroquine and sodium aurothiomalate in rheumatoid arthritis.
作者信息
Dixon J S, Pickup M E, Bird H A, Lee M R, Wright V, Downie W W
出版信息
Ann Rheum Dis. 1981 Oct;40(5):480-8. doi: 10.1136/ard.40.5.480.
Abstract
Biochemical and clinical changes have been monitored in 30 patients with rheumatoid arthritis treated with either hydroxychloroquine or sodium aurothiomalate over a period of 6 months. Acute-phase reactants improved in both treatment groups, while serum sulphydryl and serum histidine improved only in the gold-treated patients. Correlation matrices were constructed from mean clinical and biochemical data at successive clinic visits. Correlations obtained with gold were more frequent and of a higher level of significance than those obtained with hydroxychloroquine at the doses we studied. This lends support to the use of correlation matrices as a screening test for potential long-term antirheumatoid activity of drugs in man.
摘要
对30例类风湿性关节炎患者使用羟氯喹或硫代苹果酸金钠进行了为期6个月的治疗，并监测了其生化和临床变化。两个治疗组的急性期反应物均有所改善，而血清巯基和血清组氨酸仅在接受金制剂治疗的患者中有所改善。根据连续几次门诊的平均临床和生化数据构建了相关矩阵。在我们研究的剂量下，与金制剂相关的相关性比与羟氯喹相关的相关性更频繁且具有更高的显著性水平。这支持了将相关矩阵用作筛选人体药物潜在长期抗类风湿活性的测试方法。
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本文引用的文献
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Discriminatory indices of response of patients with rheumatoid arthritis treated with D-penicillamine.青霉胺治疗的类风湿关节炎患者的反应鉴别指数
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A biochemical comparison of alclofenac and D-penicillamine in rheumatoid arthritis.阿氯芬酸与青霉胺在类风湿性关节炎中的生化比较。
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On the effects of antirheumatic drugs on protein sulphydryl reactivity in human serum.抗风湿药物对人血清中蛋白质巯基反应性的影响
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