Simioni P, Prandoni P, Burlina A, Tormene D, Sardella C, Ferrari V, Benedetti L, Girolami A
Institute of Medical Semeiotics, University Hospital of Padua, Italy.
Thromb Haemost. 1996 Dec;76(6):883-6.
In a case-control study, fasting total homocysteinemia was determined in 208 consecutive outpatients who underwent phlebography because of the first episode of clinically suspected deep-vein thrombosis (DVT) of lower limbs. Contrast venography confirmed the clinical suspicion in 60 patients (28.8%). Hyperhomocysteinemia was detected in 15 of the 60 patients with DVT (25.0%), and in 17 of the 148 subjects without thrombosis (11.5%; p = 0.025). The OR for having an acute DVT in patients with hyperhomocysteinemia was 2.6 (95% CI: 1.1-5.9). It is concluded that high plasma homocysteine levels are significantly associated with DVT in symptomatic patients. Further studies are needed to clarify the clinical implications of this association.
在一项病例对照研究中，对208名因首次临床怀疑下肢深静脉血栓形成（DVT）而接受静脉造影的连续门诊患者测定了空腹总同型半胱氨酸血症。静脉造影证实60例患者（28.8%）临床怀疑成立。60例DVT患者中有15例（25.0%）检测到高同型半胱氨酸血症，148例无血栓形成的受试者中有17例（11.5%）检测到高同型半胱氨酸血症（p = 0.025）。高同型半胱氨酸血症患者发生急性DVT的比值比为2.6（95%可信区间：1.1 - 5.9）。结论是，有症状患者的血浆高同型半胱氨酸水平与DVT显著相关。需要进一步研究来阐明这种关联的临床意义。
