Raaschou-Nielsen O, Olsen J H, Hertel O, Berkowicz R, Skov H, Hansen A M, Lohse C
Danish Cancer Society, Division for Cancer Epidemiology, Copenhagen O, Denmark.
Sci Total Environ. 1996 Oct 28;189-190:51-5. doi: 10.1016/0048-9697(96)05190-x.
This exposure study addresses the validity of the exposure assessment method of an epidemiological study of traffic-related air pollution and childhood cancer. In particular, this paper concerns the question of whether the concentration of nitrogen dioxide (NO2) outside the front door is a valid marker of the exposure of the child living at the address. The study includes 100 children living on streets with dense traffic in central parts of Copenhagen and 100 children living in rural areas. Preliminary results, based on 25% of the study subjects, suggest that both the outdoor NO2-concentration and the exposure of the children are two to three times higher in Copenhagen than in the rural districts. Moreover, the results suggest that the NO2-concentration outside the front door is a poor marker of the exposure of the children in Copenhagen, but a marker of some relevance for the exposure of the children in rural districts. The preliminary results must be treated with caution, as among other things, the analysis did not consider seasonal changes and indoor NO2-sources such as passive smoking, candles, and gas appliances.
这项暴露研究探讨了一项关于交通相关空气污染与儿童癌症的流行病学研究中暴露评估方法的有效性。具体而言，本文关注前门外部二氧化氮（NO₂）浓度是否是居住在该地址儿童暴露情况的有效指标这一问题。该研究包括100名居住在哥本哈根市中心交通密集街道的儿童和100名居住在农村地区的儿童。基于25%的研究对象得出的初步结果表明，哥本哈根的室外NO₂浓度和儿童的暴露量均比农村地区高出两到三倍。此外，结果表明前门外部的NO₂浓度对于哥本哈根儿童的暴露情况而言是一个较差的指标，但对于农村地区儿童的暴露情况有一定相关性。这些初步结果必须谨慎对待，因为除其他因素外，分析未考虑季节变化以及诸如被动吸烟、蜡烛和燃气器具等室内NO₂来源。
