Batsakis J G, Mackay B, el-Naggar A K
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, USA.
Ann Otol Rhinol Laryngol. 1996 Oct;105(10):838-43. doi: 10.1177/000348949610501014.
The primitive neuroectoderm and its progeny seemingly give rise to an ever-increasing number of clinicopathologic entities. Ewing's sarcoma and peripheral primitive neuroectodermal tumor have recently been united by relatively unique antigens expressed by the MIC-2 gene, commonly coexpressed neural markers, and cytogenetic and molecular genetic abnormalities. Because of these factors, the current thinking is that Ewing's sarcoma and the peripheral primitive neuroectodermal tumor are parts of a phenotypic spectrum. We present an "interim report" on this group of neoplasms, emphasizing their presentation in the head and neck.
原始神经外胚层及其后代似乎引发了越来越多的临床病理实体。尤因肉瘤和外周原始神经外胚层肿瘤最近因MIC-2基因表达的相对独特抗原、共同表达的神经标志物以及细胞遗传学和分子遗传学异常而被归为一类。由于这些因素，目前的观点认为尤因肉瘤和外周原始神经外胚层肿瘤是表型谱系的一部分。我们给出关于这组肿瘤的“中期报告”，重点强调它们在头颈部的表现。
