Laloraya M, Jain S, Thomas M, Kopergaonkar S, Pradeep Kumar G
School of Life Sciences, Devi Ahilya University, Indore, Madhya Pradesh, India.
Biochem Mol Biol Int. 1996 Aug;39(5):933-40. doi: 10.1080/15216549600201082.
This study is undertaken to identify the regulatory switch for the activation of superoxide radical generation pathway and repression of superoxide dismutase (SOD) at the time of implantation using estrogen as a control factor and delayed implantation as a model system. The results revealed high SOD activity and negligible oxyradical generation in progesterone-treated animals on day-5 and day-8 (delayed implantation) while an enormous rise in oxyradical generation and an abrupt fall in SOD in animals which received both estrogen and progesterone injections were observed on days 5 and 8 of pregnancy. These results strongly suggest that estrogen regulates superoxide anion radical generation by lowering the SOD activity.
本研究旨在以雌激素作为对照因子，以延迟着床作为模型系统，确定着床时超氧自由基生成途径激活和超氧化物歧化酶（SOD）抑制的调控开关。结果显示，在第5天和第8天（延迟着床），用孕酮处理的动物体内SOD活性高，氧自由基生成可忽略不计，而在怀孕第5天和第8天，同时接受雌激素和孕酮注射的动物体内氧自由基生成大幅增加，SOD急剧下降。这些结果有力地表明，雌激素通过降低SOD活性来调节超氧阴离子自由基的生成。
