Laloraya M, Kumar G P, Laloraya M M
School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.
Biochem Biophys Res Commun. 1989 Jun 15;161(2):762-70. doi: 10.1016/0006-291x(89)92665-x.
Superoxide anion radical and superoxide dismutase, the enzyme responsible for dismutating it, are both present in the ovary and uterus of Mus musculus during early pregnancy. The detectable, stable levels of superoxide radical and the constant high levels of superoxide dismutase in the ovary during early pregnancy suggests that these may be involved in the regulation of extended luteal steroidogenesis for the maintenance of pregnancy. An inverse correlation between the levels of superoxide anion radical and superoxide dismutase in the uterus is shown. The high levels of superoxide anion radical in the uterus on the early morning of Day 5 of pregnancy point towards a probable role for this radical in the act of implantation and in mediating the increased vascular permeability at the initiation of implantation.
超氧阴离子自由基及其负责歧化的酶超氧化物歧化酶，在小鼠妊娠早期的卵巢和子宫中均有存在。妊娠早期卵巢中超氧自由基可检测到的稳定水平以及超氧化物歧化酶的持续高水平表明，这些可能参与了延长黄体类固醇生成以维持妊娠的调节过程。子宫中超氧阴离子自由基水平与超氧化物歧化酶水平呈负相关。妊娠第5天清晨子宫中超氧阴离子自由基的高水平表明，该自由基可能在着床过程中以及在着床开始时介导血管通透性增加中发挥作用。
