免疫接种针对泌乳山羊乳汁分泌自分泌抑制剂的效果。
Effects of immunization against an autocrine inhibitor of milk secretion in lactating goats.
作者信息
Wilde C J, Addey C V, Peaker M
机构信息
Hannah Research Institute, Ayr, UK.
出版信息
J Physiol. 1996 Mar 1;491 ( Pt 2)(Pt 2):465-9. doi: 10.1113/jphysiol.1996.sp021230.
Abstract
- Lactating goats were immunized against the goat's milk protein identified as a feedback inhibitor of lactation (FIL). Immunization was by three treatments during the declining stage of lactation. 2. When antibodies to FIL were consistently detected in milk (in response to the third treatment), the rate of decline in milk secretion was significantly reduced compared with sham-immunized controls. Such a response was not apparent with the first two treatments when serum but not milk titres of anti-FIL were raised. 3. When one gland of immunized goats was switched (after the third immunization) from twice- to once-daily milking, the ipsilateral decrease in the rate of milk secretion was reduced significantly compared with sham-immunized goats. 4. The results are compatible with the hypothesis that the autocrine agent FIL acts during milk accumulation as an inhibitor of milk secretion.
摘要
- 给泌乳山羊免疫一种被鉴定为泌乳反馈抑制剂（FIL）的山羊乳蛋白。在泌乳下降期进行三次免疫处理。2. 当在乳汁中持续检测到针对FIL的抗体时（对第三次处理的反应），与假免疫对照组相比，乳汁分泌的下降速率显著降低。在前两次处理血清中抗FIL滴度升高而乳汁中未升高时，这种反应并不明显。3. 在第三次免疫后，将免疫山羊的一个乳腺从每日挤奶两次改为每日挤奶一次，与假免疫山羊相比，同侧乳汁分泌速率的下降显著减少。4. 这些结果与自分泌因子FIL在乳汁积聚过程中作为乳汁分泌抑制剂起作用的假说相符。
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