Vajtai I, Varga Z, Bodosi M, Vörös E
Institute of Neuropathology, University Hospital Zürich, Switzerland.
Noshuyo Byori. 1995;12(2):151-4.
A case of pigmented choroid plexus papilloma removed from the 4th ventricle of a 43-year-old man is reported. The tumor showed histologic, immunophenotypic, and ultrastructural features of neoplastic choroid plexus epithelium. There was no evidence of melanosomal activity or neurosecretion. The pigment consisted of an intimate association of lipofuscin and neuromelanin, indicating autocatalytic peroxydation of the former as a putative way of melaninogenesis. The low proliferation rate of the tumor together with immunohistochemical evidence of inactivation of p53 protein suggest a delayed turnover of neoplastic cells as a possible source of lipofuscin accumulation.
报告了一例从一名43岁男性第四脑室切除的色素性脉络丛乳头状瘤病例。该肿瘤显示出肿瘤性脉络丛上皮的组织学、免疫表型和超微结构特征。没有黑素体活性或神经分泌的证据。色素由脂褐素和神经黑素紧密结合组成，表明前者的自动催化过氧化是黑色素生成的一种可能方式。肿瘤的低增殖率以及p53蛋白失活的免疫组化证据表明，肿瘤细胞的更新延迟可能是脂褐素积累的一个来源。
