Kearsey S E, Maiorano D, Holmes E C, Todorov I T
Department of Zoology, University of Oxford, England.
Bioessays. 1996 Mar;18(3):183-90. doi: 10.1002/bies.950180305.
The regulatory mechanism which ensures that eukaryotic chromosomes replicate precisely once per cell cycle is a basic and essential cellular property of eukaryotes. This fundamental aspect of DNA replication is still poorly understood, but recent advances encourage the view that we may soon have a clearer picture of how this regulation is achieved. This review will discuss in particular the role of proteins in the minichromosome maintenance (MCM) family, which may hold the key to understanding how DNA is replicated once, and only once, per cell cycle.
确保真核生物染色体在每个细胞周期精确复制一次的调控机制是真核生物的一项基本且重要的细胞特性。DNA复制的这一基本方面仍未得到充分理解，但最近的进展使人们有理由相信，我们可能很快就能更清楚地了解这种调控是如何实现的。本综述将特别讨论微小染色体维持（MCM）家族中蛋白质的作用，它们可能是理解DNA如何在每个细胞周期复制一次且仅复制一次的关键。
